Yes, it can. If you want to keep the center design-cut a big square-as is for a square quilt or a round for an applique. But, I would try Phillips FiberArts Triangles; but once you cut it its cut. So, I would sorta try to draw it out on paper or EQ7 to see which way you might possible do it. Any Fabric an be quilted; may not be that good but it can be. OR-just use it as whole cloth quilt--border it and back it and quilt it as is. Wow; Have Fun Playing with your fabric.