Yes, I quilted a design in the open spaces of a triple Irish chain quilt for my niece's wedding. It turned out very nicely. Don't hoop the quilt, just the stabilizer, pin it well and do a basting, or fix ( or whatever your machine calls it) stitch to anchor the quilt before you start. Be sure you have the fabric well supported, so the weight of the quilt does not affect the way the embroidery unit is working.