Becca, you're getting a lot of good ideas - isn't this a great place?! Here is the inspiration for a signature quilt I made - a going away gift for a quilter, boy was I nervous.
It went together quickly and made a large quilt with the solid blocks. I bound it with a scrappy binding which really set it off.
Couple of tips - definitely iron your blocks to freezer paper; next time I'll cut the freezer paper finished block size and press the seam allowance under = no lost signatures; have some scraps for the signers to test writing on; test your pen on scraps for permanency - even though I had pre-washed fabric and used Pigma pens, I still had to heat set.
Be sure to post a pic of the finished quilt! :-)