Letters ... using your three initials ... one initial should represent the main color, another initial should represent the pattern or block, and the third initial should represent the quilting motif - any initial can be any item. Creative license allowed with colors and quilting motifs (ie blue can be aqua, stipple can be meander, etc.)
Example: Annette Delores Baker could be Drunkards Path blocks in Aqua and quilted with Baptist Fan.
The next one will really get the creative juices flowing ....
Clue!! Each person chooses three cards from a standard "Clue" game. They then have to represent those three 'clues' somehow in their quilt. The people (Professor Plum, Ms. Scarlet etc) could be easy as they can represent the color (but they don't have to), the rooms and weapons will be the tricky part.
The Rope ... could be a rope quilting motif, or a couched thread as an embellishment
Lead Pipe ... something grey, something long and thin
Conservatory ... use floral fabric, applique flowers and vines
Example: Mrs Peacock in the Dining Room with the Revolver could be Peacock feathers forming a Dresden Plate (dining room), quilted in concentric circles (revolver).
There are lots of possibilities, but folks will definitely need their thinking caps for this one.