It's a very good idea. There are some techniques especially for reversible quilts. Check out the following sites. I've tried two of the techniques. The last one is for using a serger instead of a regular sewing machine.
http://www.quiltyard.com/whatiscottontheory.phtml
http://www.diynetwork.com/diy/shows_qlt/article/0,2045,DIY_15080_2505414,00.html
http://www.quiltingworks.com/cabin-fever/projects/quiltasyougo.htm
http://www.hgtv.com/hgtv/cr_quilting_tips/article/0,,HGTV_3307_1376658,00.html