As has been said, NYC has so much to offer depending on what your interests are. There is a site which has wonderful information including a travel guide, maps, event calendar, links to the top must-see sites.
http://www.nyc.com/events
I was born in the Bronx and went to college there as well. There are so many wonderful restaurants like the Russian Teahouse, L'etoile, Mama Leone's. Be adventurous and foods you can't get at home. And they are right about the pizza; I miss that - especially the Sicilian.
I agree the shops in the garment district can be so fun. I remember one with ribbons and trim. Sensory overload.
Have fun.