My first quilt was a mix of cotton prints and poly cotton sheets as the solids with a sheet for the back. After piecing it and before quilting , I read that this could be a problem since the cottons and blends would shrink differently. I finally bit the bullet and quilted it on my DSM. It has worn and washed beautifully. Been on my bed for a year now, and I sleep with my dogs. I say go for it.