Hobbs Tuscany Wool batting is my preference. However, it doesn't come in white or at least I haven't been able to find it so for my white background tops I go to cotton. I think I used Dream Cotton. I have used silk, but for the money I much prefer wool. I have never used 80/20 in any brand. Whatever you choose, it depends on how closely you are going to be quilting and what drape you want. I suspect the 80/20 won't shrink as much as the all cotton. I bought a bundle of batting squares from Harriet Hargrave's web store. There are 14 or 16 (I think) 12 x 12 squares of different bats. I usually take one of those samples and hand quilt a small area to see how well that particular bat needles. I think it's Fairfield cotton that is absolutely sumptuous, but it doesn't come in large sizes. The only bat that I will never use again is polyester. I used Dream Poly in the quilt I'm working on now because I didn't want any shrinkage, but the bearding is bad and the drape is stiff.