I saw a news report several years ago (might have been Sixty Minutes but I am not sure) regarding womens purses. It showed that the bottom of the purses were highly contaminated with bacteria, inluding E-coli. One of the places, were a lot of the women were getting the germs, was in public restrooms. Apparently many women set their purses on the floor when they are using the restrooms. Yuck! Also, remember that when you set your purse, or bags, in a shopping cart seat that you pick up whatever germs the last person left when they set theirs purse or bags in there. Don't forget to wipe the seat, along with the handle, with the wipes that most stores provide these days.