I use Wonderunder for fusible appliqué and a machine buttonhole stitch around the edge. For large appliqués, I "window" the pieces. That is where you remove the Wonderunder center leaving about 1/2 inch ( 1/4 inch outside the line and 1/4 inside the line) before fusing it the the back of the fabric and cutting it out. This makes the large pieces softer in the quilt. With Mistyfuse you may not need to window but I haven't used it before?