I have taken Nabumetone and Sulfasalazine (an old antibiotic for inflammation) for several years now. Usually after a few years they stop working and I have to change meds. I was diagnosed 21 years ago at 32 years old with rheumatoid arthritis. I have done it all, including gold shots. Have had two neck surgeries, four foot surgeries, and four knee surgeries, including a complete knee replacement, because of arthritis. I've learned to put my feet up whenever I get a chance.