I always stay at the Lancaster Arts Hotel. It's beautiful and clean, a bit more expensive than some others, but included in the price you also get unlimited free taxi service to anyplace within 5 or 7 miles (I forget which), so that gets you to and from the quilt show anytime you want, without having to drive in narrow crowded streets and having to find and pay for parking or walking a mile to your car. You'll walk enough at the show, believe me! Anytime you're ready to go back to the hotel, you just call them and they send a taxi. Then you get ready for dinner, and take another free taxi...Sew convenient! Once I check in, my car doesn't move again until I'm going home.
