It would be a nice little trip, so go to Quilt in a Day:
http://www.quiltinaday.com/contact/
I know if I was that close I would make the trip. I have gone shopping in their Paducah store a while back when DH took me to the quilt show there.
Looking at google maps most of the trip would be on Interstate 5. A good ocean view most of the way!
Happy Shopping!