I'm currently doing FMQ on a 52" x 52" (largest I've made) and I'm doing it in quarters. I don't roll it because as others have said it makes it too stiff, but I do bunch it up in the throat of the machine. I start in the top center and sort of go down and up and across until I reach the edge that is on the right. Then I turn the quilt and now I have a top center part to start with again. I sew on a dining table that has an extension I can pull out of the end to support the quilt, but I've also set up my ironing board sort of on a diagonal behind my left arm. Hope that helps.