We have a one level ranch home so my sewing room is in the basement. I miss not having alot of natural light but I love the fact that it is in an area that no one sees. The cement floor is easy to keep clean and needles/pins are easy to find.
My DH sewing machine repair business is in the other half of the basement so we can talk to each other. We spend so much time down there that we sometimes think we should take in a boarder for the main level. (not!) The only thing I miss is the natural light.