I've done 2 large quilts QAYG in a way that works for me; may not appeal to others as the back of the quilt is very plain. I make and quilt the individual blocks with just batting & block. I join them all together with sashing. I then attach my backing in one (or pieced) large piece and stitch in the ditch along all the sashing strips. The back only has a grid style quilt pattern on it when finished but the front is quilted as I want. If you don't mind a rather plain looking backing (I always pick a nice print) this is a pretty easy method. The only time the whole quilt is in the machine is to quilt along all the sashings.