I'm just now quilting my first "big" project (after making a tablerunner to familiarize myself with the process). I'm surprised to find myself really enjoying the quilting. Aside from wrestling with the fabric, I find the process very satisfying.
For me, the scariest/hardest part is choosing fabrics and putting them together in the pattern. I do not have very good color sense so I always worry I'm going to make something ugly.