Susan: I've used glue on a couple of my quilts recently, including the binding, and it has not created any problems with the needles. When sandwiching, I just sprinkle glue around, flatten out if there are any clumps so it isn't too think in one place, and let it dry overnight. For binding, I just put a few drops on and iron it. The heat will dry it so you can do the binding right away. The first time I did a quilt using this method, it was a full-size quilt. It was so nice not to have to worry about shifting when FMQing. The back of the quilt looked so good when I was finished (with no pleats or anything else) that my husband laughed at me doing a happy dance!