I can relate to your "nervousness". Last winter I made a quilt for someone from all her 5 children's baby clothes. She was very sentimental about them and it also included her son's baby blanket that had died as an infant. It took me many evenings of laying out the pieces to see what went well together and then leaving it alone for a couple of days to give me a chance to change my mind. The first cut was the hardest but in the end it was a quilt I was very proud of and she loved it.
I also used alot of interfacing as she had knits, demin, nylon, and even a baby sock. Good luck with your project. Just take your time.