I think a serger would do nicely for a quilt with large pieces. The thread will add more weight to the quilt, but serger thread is a lot cheaper than the other threads we use for piecing. You sure wouldn't have to worry about seams coming out. I usually serge around the outer edge of my quilt top when I finish piecing it. I tend to be slow about getting them quilted and this keeps seams from pulling out. Go for it if its something you want to try.