I have locking casters/wheels on my homemade table for my HQ. To be honest I hardly need them since I got the computerized ProStitcher.
The main thing to be aware of is the state of your floor. If it is even then this should not be a problem. I know this because my machine quilting group uses a store machine that keeps being moved and it is really hard for me to use free motion quilting. That floor is not level. At least we were told the problem is because of all the moving.