Bottom line, yes there is a right and wrong side. I know there was a discussion here on the board a bit ago that you might be able to search for more info. BUT, I've used W&N batting for years; have never paid attention (honestly didn't even know about right/wrong side) and have never had an issue. I hand quilt. I think there would be even less of an issue (if one even really exists) if you are machine quilting. Just my 2 cents.