In my thinking, you may not always lay with the quilt the same direction, when it is folded that changes the direction also. I would do the layout on the floor and then maybe make them random. If it was a wall hanging and was always displayed the same direction is when it is critical in my mind.
Welcome to the board and we love to see pictures of what you are working on. Remember, there are no dumb questions. We have all been there or done that.