No! Hand quilting thread has a finish on it so it doesn't tangle as easily as regular thread. However, that finish gums up the tension mechanism in a sewing machine. Using it in a machine can result in a costly repair service call!
Regarding batting, a lot of hand quilters really like Quilters Dream cotton in Select or Request weight. This is a thin batting. If you are looking for a little more "poof", then Hobbs 80/20 is a good choice and still easy to quilt.