I listen to Dr. Oz, then do my research and then run it by a nutritionist. Mixing pharmaceuticals and OTC supplements can cause problems, so research is needed. I would rather take vitamins and natural supplements over artificial prescriptions ... but that is just me. As far as wrinkles, I do use a sunscreen moisterizer (and have done so for years) but some of those products are more problematic than practical. Anyway, I figure I've earned those wrinkles and each one is a life experience.