you can hand quilt- but the appliques need to be stitched down- using fusible usually makes it difficult to hand stitch the applique down- so generally fusible raw edge applique is machine applique. hand applique is needle turn- without fusible used. but you can still hand quilt a quilt made with raw edge appliques- most of the time appliques are not stitched through during the quilting process- so it doesn't matter if it's hand or machine (needle turn or fusible-raw edge)