My work station (cutting, stitching, press & trimming) is in the center of the room. I love it there!
If I am doing paper piecing or straight piecing, this works beautifully for me - no up and or twisting and turning. If I am doing marathon appliqueing, I move my machine to a sit-down area.
I have the natural light toward my machine, I can see out the windows and I can easily access other work areas around the room.
And, if you find you don't like it, it's not carved in stone so you can just change it up. Easy peasy.
best,
d