I know the feeling, my kids are 22 months and 2 months! The best advice I can give, is in the morning before they get up, go and set up whatever project you want to work on (get bobbins wound, machine threaded ect). Then, impose a quiet time. Choose 1 hour a day (right after lunch works for my 22 mo old), and tell the kids that the only rule is that they must stay on their beds. Let them take a few toys, a book, whatever. Separate them if you have to by putting one kid on your bed or maybe on separate couches? Whatever works in your house. Then quilt for that hour!