I took a class on craftsy on quilting large quilts with DSM. It is very possible. You need to baste it real good, but as you quilt you only need the area you are working on free enough to move as you work. When I first started many years ago, they told us to roll it into logs. It is much harder to work that way. Just squish it around to get the area you want to work on flat on top and smooth on the bottom. Then do what you want to do on it.