I agree with alikigirl - the Cameo requires fusible on the back of the fabric in order for the machine to cut (and a computer connection), whereas with the GO, you just put your fabric on the die and run it through the cutter. I have the Cameo and I have the Accuquilt Studio cutter, and the Cameo is only productive for cutting applique shapes (or paper/vinyl crafting) - not cutting large volume block pieces. It is basically like a Cricut machine without the need for cartridges as the designs are sent from your computer to the Cameo instead of from a cartridge.