I think either could be fine. #2 would give you great open spaces to show off your quilting, if that is what you want to do. The bottom line is it's your quilt and your decision. If I had made those blocks and chosen #1, I might rearrange blocks so that there was a large square on point using the blocks with deep red on the outside, giving an overall unification. Be sure to show us what you decide to do with these blocks.