I have successfully mixed minkee and cottons on quilt tops, I've sashed with minkee, I've made quilts with a row of cotton blocks then a strip row of minkee, I've made quilts with cotton background and minkee appliques, and I've made lots of quilts with minkee backs---I see no reason to not do it the way you want to- all of mine have turned out great, and are greatly loved & used- holding up well.