I think of thread as an extension of the design process. Pick the right one for the kind of quilt, quilting design and texture you are looking to get in your quilt. I use all of them, including glide, signature, A&E, superior, etc. I also use all fiber types of threads: cottons, ploys, blends, etc. For me, I let the quilt tell me what kind of thread would be best and then go from there. I run them all, and they are all great :-)