I can sure empathize. I'm in a purging mode right now. Have done the rest of the house, and the sewing room is last. I'm looking at EVERYTHING as "If I have to move, do I want to pack it, move it, unpack it, and find a place to store it?" If the answer is no, it's gone. I've got so many quilty notions I've bought and found just don't work for me. Why keep them? After a while, you know what works and what doesn't. Multi-taskers - that's what I like. Quilting is actually one of the most simplistic of crafts - you don't need fancy stuff to do it. Sometimes you just have to stop and think about how important "things" really are. Too much clutter = cluttered life. Fabric? No, I'll keep that, just cut down on what I buy. I've got 8 rubbermaid containers of it, sorted by color, and I won't buy more than what can fit into those 8 containers. Period. Sometimes you just have to police yourself.
That being said, I also clean my room completely between every quilt. As soon as that quilt is finished. Everything gets put away in it's proper place (and yes, it took me years to perfect that habit!), the entire room gets dusted, needle and rotary blades get changed, and bobbins re-wound (I use only two colors to piece - parchment for light fabrics, dark grey for dark fabrics). That way, when I start my next quilt, I'm completely ready!