Originally Posted by
knlsmith
Go for it! I mix cotton, batiks, woolies, flannels. Prewash before cutting, then starch n iron. The only limitation is your imagination. ♡
What knlsmith said! Prewashing in hot water and machine drying is a MUST if you are going to mix cottons with blends or non-cottons such as fleece. Cotton will always shrink some, blends such as poly-cotton will shrink a little, and poly fabrics including fleece will not shrink. Your quilt will end up really wonky the first time it's washed if you do not prewash before you start cutting blocks.
I'm sure any small child will love a quilt with the different textures so go for it!