I got sick from a form of chemo and at the time there was a quilt I hated - a charity cheater cloth that wasn't square in the print at all!- on the frame. I finally quilted the thing just to get rid of it almost 2 years later. Of course it took me a while to do the quilting as I was still recovering. Being on the frame certainly didn't hurt the quilt.
I had unplugged the machine when I got sick knowing I wouldn't be using it for quite a while.