I agree with Dottymo.. Piece the large red and white parts, then applique the lettering and other things.. cut out the center parts of the bigger applique pieces and just leave a half inch along the edges that you are going to applique (if you're planning on machine applique).. It will be great!!
Welcome to the board... I hope there isn't a deadline on your quilt.. you'll need more time than you would have thought, to make up for the lost time you'll spend on here!!!