I have only just finished my second ever quilt - it's a queen size and was done on an inexpensive domestic machine with a standard throat. I 'stitched in the ditch' for the quilting (there was a lot as I used several jelly rolls).
I won't say it was easy, and it was made a bit more difficult because I used a heavy, high-quality king size flannel sheet for the backing. I did a lot of rolling of both sides and at some points had those rolls over my shoulders.
Despite the awkwardness of it, I certainly won't be shying off doing another one.