When you're working in the "quilt" window, click on the bottom tab that says "Layout". You can change the number and size of the blocks. If you want to change it from a horizontal layout to an on-point layout, you need to go to the top bar of the tools menu, click "Quilt", then click "New Quilt" and you can create on point, variable point, horizontal, whatever you want.
Did you receive a manual with your program? It should be a great help to you. I learned EQ7 simply by messing around with the program and looking up what I wanted to do in the manual.