I tried basting spray on my first ("practice") quilt, which is king-sized, but found it did not do the job for me. My quilt still had funky little lumps, bumps and wrinkles. From there, I tried hand basting (very labor intensive). Now I smooth the 3 layers, pull them taut, clip them to the edges of a plywood slab and then use quilter's safety pins. The safety pin method leaves me with no weird lumps, bumps, or wrinkles, but I sure have to be careful when I'm machine sewing not to catch a pin on the needle clamp screw; I've done that more than once!
Back to the subject of spray, I use it when I do machine embroidery, but I hold my breath so as not to inhale it and then quickly move to a different area of the house before I take another breath. To me, that stuff seems lethal. To be fair, though, I cannot tolerate any aerosol spray, including air freshener.