I have used it on several quilts. I use Hobbs 80/20 fusible and it does take some work to iron a large quilt. I do mine on my basement floor on old carpet. I put on my knee pads and it takes about an hour. I lay the back out first, spread the batting on top of the back and then lay the top on. I start ironing from the center out so any extra fabric goes to the edge. Once the top is all fused ( the back is somewhat fused from the iron too) I flip over the sandwich and iron the back starting from the middle too. I put safety pins around the quilt sandwich edge to keep the edges from peeling up as I move the sandwich through my machine.
I have used 505 spray and I like that too. The Elmer's washable glue works too but I have only done a lap quilt with it.