Thanks so much for the feedback everyone! I am drawn to A too which is odd because I normally go for a diagonal secondary pattern every time.
Layout B really plays on value - which I really needed to pay more attention to in my construction as several of these blocks are too muddled. When I look at B too long all I see are the blocks I'd need to take out! But I love the "argyle" effect.
So for this set of blocks it will be A - but I want to try B in the future. Good thing I've got bins of 5" charms ready to play with!