I am right handed, but a few years ago I had surgery on my right thumb and had a cast then brace for 8+ weeks. I learned to do many, many things with my left, rotary cut among them. I never went back to my right to use my mouse...it just seems natural to use the left. I think many people would learn to use the "Other" hand if they had to. I could not go 8 weeks without sewing.