I've done a lot of quilt-as-you-go. I loved the portability of block by block. The question to ask yourself is whether you like finishing work or not? There is a lot of finishing once you have the blocks quilted to assemble the rows. The thing to remember is to not quilt within 1/2 inch of the edge as this is your sewing line.
I can no longer hand quilt, so now do machine quilt-as-you-go. However, for that, I do section by section or row by row.