The smaller the needle the better and closer the stitch. It also helps if the fabric is loosely woven and the batting is extra thin. It also is easier if you are not using a frame or hoop. As a hand quilter for at least 40 years I have done it all. I have done at least 100 quilts by hand. They have been all shapes and sizes. In the long run being consistent in size and spacing is what counts. I will warn you that after 40 years I am wearing out my hands and elbows. Don't worry about the number of stitches.