I am in the process of doing a quilt in reds and white (with small red print). Reds (possibly oranges or any other color) will bleed. I use a dye setting product so I never have to be concerned whether I have color catchers on hand! I'd much rather go to the time and expense to set the dye than risk ruining the quilt -- that's too much work to waste!
JMHO
Jeanette Frantz