Oh honey, anything that makes you happy will work. No quilt police are allowed on this board so there are no rules to break here. What you talked about--large blocks with sashing between, should turn out simple but elegant and can be the canvas for some very interesting quilting. My only concern would be 'too much of a good thing'. You might get very tired of just cream and red.
What about exploring a complementary colour option. Maybe add some charcoal or black or figured fabric or a brilliant royal blue or....well just not limit yourself to two colours unless that is absolutely what your heart is set on.
Can't wait to see what you decide.