I have carpal tunnel so I can relate. When I use Elmer's School Glue I dilute it a bit.
Saves glue and you don't get those thick spots under the needle. I apply the glue
like I'm writing with the bottle. I put the batting down, apply the glue then apply the
top or backing on it. Don't worry, there's more glue than you think. A little goes a long
way with Elmer's. I would also suggest wearing a wrist brace and taking a few breaks.