Fleece makes a great batting. I've used it in many quilts, charity and not charity. I have both spray basted/not spray basted before putting the quilt sandwich on the frame to machine quilt. It turns out fine. I've only had a wrinkle on the back of a quilt once. I think it happened because the tension of the quilt on the frame was off.
I can give you no advice on which batting is best for hand quilting because I've never hand quilted. If you plan to quilt on your dsm, I recommend that you pin baste heavily - otherwise the fleece does shift all over the place.
It's nice to have the fleece for a number of reasons: It comes in 60" widths. Most of the quilts I make are more than 40" but less than 60", so I can use it on most of the quilts I make. It drapes really well, and the quilt feels softer than when cotton or polycotton is used. It comes in at least 2 weights and the lighter weight is extremely lightweight for use in baby or toddler quilts. The lighter weight makes it easier for a little one to drag around and love to tatters!
For larger quilts I use cotton or poly/cotton blend. That works fine, too.