I haven't bought many fabrics from the new collections - I tend to haunt clearance bins, like some of the other posters! Occasionally I'll use a large scale print (especially home dec style) for the back of placemats so that one side is a little bitty pieced design, and the other is a big bold fabric print, which gives full reversibility without fussing with making two separate pieced sides. That's a function choice, though, and not really what I think Holice was asking about.
Another approach I've taken with large scale stuff is to make blocks that have a border, or edging (could even be four squares in the corner, doesn't have to be contiguous) and fussy cut so that it looks like the large scale print is behind the other pieces - sort of like a fractured pattern. Time consuming, and wasteful, but can look pretty cool.
Alison